Article
Mycophenolic acid-related diarrhea is not associated with polymorphisms in SLCO1B nor with ABCB1 in renal transplant recipients.
Pharmacogenetics and genomics - 1 Jun 2012
Bouamar Rachida, Hesselink Dennis A, van Schaik Ron H N, Weimar Willem, van der Heiden Ilse P, de Fijter Johannes W, Kuypers Dirk R J, van Gelder Teun
Abstract excerpt
OBJECTIVE: We investigated the association between genetic polymorphisms in ABCB1 and SLCO1B and mycophenolic acid (MPA) pharmacokinetics, and MPA-related diarrhea and leukopenia in 338 kidney transplant recipients. METHODS: A total of 338 patients participating in an international, randomized-controlled clinical trial were genotyped for ABCB1 and SLCO1B. Patients were all treated with mycophenolate mofetil and...
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