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Article

SLCO1B1 genetic polymorphism influences mycophenolic acid tolerance in renal transplant recipients.

Pharmacogenomics - 1 Dec 2010

Michelon Hugues, König Jörg, Durrbach Antoine, Quteineh Lina, Verstuyft Céline, Furlan Valérie, Ferlicot Sophie, Letierce Alexia, Charpentier Bernard, Fromm Martin F, Becquemont Laurent

Abstract excerpt

AIMS: This study aimed to determine the influence of gene candidates on mycophenolic acid (MPA) response during the first year of renal transplantation. MATERIALS & METHODS: A total of 218 renal transplant recipients who received MPA from the first day of transplantation at a fixed dose of 2 g/day were genotyped for ABCB1, ABCC2, UGT2B7, UGT1A9, SLCO1B1, SLCO1B3 and IMPDH1 polymorphisms. Clinical end points were...

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Source

Identifiers

PMID: 21142914
DOI: 10.2217/pgs.10.132

Genes

ABCB1
ABCC2
IMPDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SLCO1B1 genetic polymorphism influences mycophenolic acid tolerance in renal transplant recipients.PMID 21142914Read ↗

Influence of SLCO1B1 Polymorphisms on the Pharmacokinetics of Mycophenolic Acid in Renal Transplant Recipients.Semantic proximity Read ↗

Influence of genetic polymorphisms on pharmacokinetics and treatment response of mycophenolic acid: a scoping reviewSemantic proximity Read ↗

The Impact of Genetic Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Mycophenolic Acid: Systematic Review and Meta-analysis.Semantic proximity Read ↗

Influence of Genetic Polymorphisms on Mycophenolic Acid Pharmacokinetics and Patient Outcomes in Renal Transplantation.Semantic proximity Read ↗

C-440T/T-331C polymorphisms in the UGT1A9 gene affect the pharmacokinetics of mycophenolic acid in kidney transplantation.Semantic proximity Read ↗

Influence of UDP-Glucuronosyltransferase Polymorphisms on Mycophenolic Acid Metabolism in Renal Transplant Patients.Semantic proximity Read ↗

Multidrug resistance protein 2 genetic polymorphisms influence mycophenolic acid exposure in renal allograft recipients.Semantic proximity Read ↗

The reduced function allele SLCO1B1 c.521T>C is of no practical relevance for the renal graft function over the first post-transplant year in patients treated with mycophenolic acid.Semantic proximity Read ↗

Effect of UGT polymorphisms on pharmacokinetics and adverse reactions of mycophenolic acid in kidney transplant patients.Semantic proximity Read ↗

The reduced function allele SLCO1B1 c.521T>C is of no practical relevance for the renal graft function over the first post-transplant year in patients treated with mycophenolic acidSemantic proximity Read ↗

Effect of hepatic drug transporter polymorphisms on the pharmacokinetics of mycophenolic acid in patients with severe renal dysfunction before renal transplantation.Semantic proximity Read ↗

The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants.Semantic proximity Read ↗

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