Article
The reduced function allele SLCO1B1 c.521T>C is of no practical relevance for the renal graft function over the first post-transplant year in patients treated with mycophenolic acid.
Pharmacogenetics and genomics - 1 Sept 2024
Nađ Škegro Sandra, Penezić Luka, Šimičević Livija, Hudolin Tvrtko, Kaštelan Željko, Božina Nada, Trkulja Vladimir
Abstract excerpt
OBJECTIVE: It is unclear whether renal transplant recipients treated with mycophenolic acid (MPA) who carry the reduced-function allele at polymorphism SLCO1B1 c.521T>C differ from their wild-type peers regarding renal outcomes and tolerability. We aimed to estimate the effect of this polymorphism on the graft function (estimated glomerular filtration rate, eGFR) over the first 12 post-transplant months in...
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