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Influence of SLCO1B1 Polymorphisms on the Pharmacokinetics of Mycophenolic Acid in Renal Transplant Recipients.

Current drug metabolism - 1 Jan 2023

Liu Jiawen, Zhu Yongqian, Zhang Jiexiu, Wei Jintao, Zheng Ming, Gui Zeping, Chen Hao, Sun Li, Han Zhijian, Tao Jun, Ju Xiaobin, Tan Ruoyun, Gu Min, Wang Zijie

Abstract excerpt

OBJECTIVE: This study was designed to analyze the correlation between single nucleotide polymorphisms (SNP) related to drug metabolism and pharmacokinetics of mycophenolic acid (MPA) during long-term follow-up. MATERIALS AND METHOD: A retrospective cohort study involving 71 renal transplant recipients was designed. Blood samples were collected to extract total DNAs, followed by target sequencing based on...

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PMID: 36734895
DOI: 10.2174/1389200224666230124121304

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Influence of SLCO1B1 Polymorphisms on the Pharmacokinetics of Mycophenolic Acid in Renal Transplant Recipients.PMID 36734895Read ↗

Influence of Genetic Polymorphisms on Mycophenolic Acid Pharmacokinetics and Patient Outcomes in Renal Transplantation.Semantic proximity Read ↗

The Impact of Genetic Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Mycophenolic Acid: Systematic Review and Meta-analysis.Semantic proximity Read ↗

Influence of genetic polymorphisms on pharmacokinetics and treatment response of mycophenolic acid: a scoping reviewSemantic proximity Read ↗

SLCO1B1 genetic polymorphism influences mycophenolic acid tolerance in renal transplant recipients.Semantic proximity Read ↗

Influence of UDP-Glucuronosyltransferase Polymorphisms on Mycophenolic Acid Metabolism in Renal Transplant Patients.Semantic proximity Read ↗

Effect of UGT polymorphisms on pharmacokinetics and adverse reactions of mycophenolic acid in kidney transplant patients.Semantic proximity Read ↗

The association of the UGT1A8, SLCO1B3 and ABCC2/ABCG2 genetic polymorphisms with the pharmacokinetics of mycophenolic acid and its phenolic glucuronide metabolite in Chinese individuals.Semantic proximity Read ↗

Genetic polymorphisms in metabolic enzymes and transporters have no impact on mycophenolic acid pharmacokinetics in adult kidney transplant patients co-treated with tacrolimus: A population analysis.Semantic proximity Read ↗

The reduced function allele SLCO1B1 c.521T>C is of no practical relevance for the renal graft function over the first post-transplant year in patients treated with mycophenolic acidSemantic proximity Read ↗

An integrated sampling strategy for therapeutic mycophenolic acid monitoring in lung transplant recipients.Semantic proximity Read ↗

The reduced function allele SLCO1B1 c.521T>C is of no practical relevance for the renal graft function over the first post-transplant year in patients treated with mycophenolic acid.Semantic proximity Read ↗

Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients.Semantic proximity Read ↗

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