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Article

Risk of diarrhoea in a long-term cohort of renal transplant patients given mycophenolate mofetil: the significant role of the UGT1A8 2 variant allele.

British journal of clinical pharmacology - 1 Jun 2010

Woillard Jean-Baptiste, Rerolle Jean-Philippe, Picard Nicolas, Rousseau Annick, Drouet Mireille, Munteanu Eliza, Essig Marie, Marquet Pierre, Le Meur Yann

Abstract excerpt

AIM: In renal transplant patients given mycophenolate mofetil (MMF), we investigated the relationship between the digestive adverse events and polymorphisms in the UGT genes involved in mycophenolic acid (MPA) intestinal metabolism and biliary excretion of its phase II metabolites. METHODS: Clinical data and DNA from 256 patients transplanted between 1996 and 2006 and given MMF with cyclosporin (CsA, n = 185),...

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Identifiers

PMID: 20565459
DOI: 10.1111/j.1365-2125.2010.03625.x
PMCID: PMC2883760

Genes

ABCC2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Risk of diarrhoea in a long-term cohort of renal transplant patients given mycophenolate mofetil: the significant role of the UGT1A8 2 variant allele.PMID 20565459Read ↗

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