Article
Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction.
Basic research in cardiology - 17 Aug 2017
Xu Xin, Zhang Ping, Kwak Dongmin, Fassett John, Yue Wenhui, Atzler Dorothee, Hu Xinli, Liu Xiaohong, Wang Huan, Lu Zhongbing, Guo Haipeng, Schwedhelm Edzard, Böger Rainer H, Chen Peijie, Chen Yingjie
Abstract excerpt
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthases that limits nitric oxide bioavailability. Dimethylarginine dimethylaminohydrolase-1 (DDAH1) exerts a critical role for ADMA degradation and plays an important role in NO signaling. In the heart, DDAH1 is observed in endothelial cells and in the sarcolemma of cardiomyocytes. While NO signaling is important for cardiac...
Topics
- Amidohydrolases
- Animals
- Arginine
- Atrial Natriuretic Factor
- Disease Models, Animal
- Fibrosis
- Genetic Predisposition to Disease
- Hypertrophy, Left Ventricular
- Male