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Article

Role of the alpha1D-adrenergic receptor in the development of salt-induced hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Jul 2002

Tanoue Akito, Koba Masahiro, Miyawaki Shigeki, Koshimizu Taka-aki, Hosoda Chihiro, Oshikawa Sayuri, Tsujimoto Gozoh

Abstract excerpt

In an attempt to elucidate whether there is a specific alpha1-adrenergic receptor (alpha1-AR) subtype involved in the genesis or maintenance of hypertension, the alpha1D-AR subtype was evaluated in a model of salt-induced hypertension. The alpha1D-AR-deficient (alpha1D-/-) and control (alpha1D+/+) mice (n=8 to 14 in each group) were submitted to subtotal nephrectomy and given 1% saline as drinking water for 35...

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Identifiers

PMID: 12105146
DOI: 10.1161/01.hyp.0000022062.70639.1c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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