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Article

Role of the lysine-specific demethylase 1 in the proinflammatory phenotype of vascular smooth muscle cells of diabetic mice.

Circulation research - 12 Sept 2008

Reddy Marpadga A, Villeneuve Louisa M, Wang Mei, Lanting Linda, Natarajan Rama

Abstract excerpt

Insulin resistance and type 2 diabetes are major risk factors for vascular complications. Vascular smooth muscle cells (VSMCs) derived from db/db mice, an established mouse model of type 2 diabetes, displayed enhanced inflammatory gene expression and proatherogenic responses. We examined the hypothesis that aberrant epigenetic chromatin events may the underlying mechanism for this persistent dysfunctional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Methylation

Share to Mice, Mutant Strains

Share to Muscle, Smooth, Vascular

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Share to Oxidoreductases, N-Demethylating

Source

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Identifiers

PMID: 18688044
DOI: 10.1161/CIRCRESAHA.108.175190
PMCID: PMC2693400

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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