Article
Lysine-Specific Demethylase-1 Deficiency Increases Agonist Signaling Via the Mineralocorticoid Receptor.
Hypertension (Dallas, Tex. : 1979) - 1 Apr 2020
Treesaranuwattana Thitinan, Wong Kelly Yin Han, Brooks Danielle L, Tay Chee Sin, Williams Gordon H, Williams Jonathan S, Pojoga Luminita H
Abstract excerpt
LSD1 (lysine-specific demethylase-1) is an epigenetic regulator of gene transcription. LSD1 risk allele in humans and LSD1 deficiency (LSD1+/-) in mice confer increasing salt-sensitivity of blood pressure with age, which evolves into salt-sensitive hypertension in older individuals. However, the mechanism underlying the relationship between LSD1 and salt-sensitivity of blood pressure remains elusive. Here, we...
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