Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension.

doi:10.1038/ajh.2012.43

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Article

Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension.

American journal of hypertension - 1 Jul 2012

Williams Jonathan S, Chamarthi Bindu, Goodarzi Mark O, Pojoga Luminita H, Sun Bei, Garza Amanda E, Raby Benjamin A, Adler Gail K, Hopkins Paul N, Brown Nancy J, Jeunemaitre Xavier, Ferri Claudio, Fang Rui, Leonor Thiago, Cui Jinrui, Guo Xiuqing, Taylor Kent D, Ida Chen Yii-Der, Xiang Anny, Raffel Leslie J, Buchanan Thomas A, Rotter Jerome I, Williams Gordon H, Shi Yujiang

Abstract excerpt

BACKGROUND: Hypertension (HTN) represents a complex heritable disease in which environmental factors may directly affect gene function via epigenetic mechanisms. The aim of this study was to test the hypothesis that dietary salt influences the activity of a histone-modifying enzyme, lysine-specific demethylase 1 (LSD-1), which in turn is associated with salt-sensitivity of blood pressure (BP). METHODS: Animal and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22534796
DOI: 10.1038/ajh.2012.43
PMCID: PMC3721725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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