Article
5-HTTLPR genotype and gender, but not chronic fluoxetine administration, are associated with cortical TREK1 protein expression in rhesus macaques.
Neuroscience letters - 3 Oct 2011
Bogdan R, Fitzgibbon H, Woolverton W L, Bethea C L, Iyo A H, Stockmeier C A, Kyle P B, Austin M C
Abstract excerpt
TREK1 is a widely expressed background potassium channel. Similar to mice treated with selective serotonin reuptake inhibitors (SSRIs), TREK1 knockout mice are resistant to depression-like behavior and have elevated serotonin levels leading to speculation that TREK1 inhibition may contribute to the therapeutic effects of SSRIs. This study examined how chronic fluoxetine administration and a common functional...
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