Article
Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques.
Genes, brain, and behavior - 1 Aug 2010
Kinnally E L, Capitanio J P, Leibel R, Deng L, LeDuc C, Haghighi F, Mann J J
Abstract excerpt
Epigenetic mechanisms may moderate genetic and environmental risk (GxE) for mood disorders. We used an experimental rhesus macaque model of early life stress to test whether epigenetic regulation of serotonin transporter (5-HTT) may contribute to GxE interactions that influence behavior and emoti...
Topics
- Animals
- Animals, Newborn
- Behavior, Animal
- Female
- Gene Expression Regulation
- Genotype
- Humans
- Macaca mulatta
- Maternal Deprivation
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Serotonin
- Serotonin Plasma Membrane Transport Proteins
- Social Behavior
- Social Environment
- Stress, Psychological