Article
Differential serotonin transport is linked to the rh5-HTTLPR in peripheral blood cells.
Translational psychiatry - 7 Feb 2012
Singh Y S, Altieri S C, Gilman T L, Michael H M, Tomlinson I D, Rosenthal S J, Swain G M, Murphey-Corb M A, Ferrell R E, Andrews A M
Abstract excerpt
The human serotonin transporter (SERT) gene possesses a 43-base pair (bp) insertion-deletion promoter polymorphism, the h5-HTTLPR. Genotype at this locus correlates with variation in anxiety-related personality traits and risk for major depressive disorder in many studies. Yet, the complex effects of the h5-HTTLPR, in combination with closely associated single-nucleotide polymorphisms (SNPs), continue to be...
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