Article
Dominant negative effects of a non-conducting TREK1 splice variant expressed in brain.
The Journal of biological chemistry - 17 Sept 2010
Veale Emma L, Rees Kathryn A, Mathie Alistair, Trapp Stefan
Abstract excerpt
Two-pore domain potassium (K(2P)) channels modulate neuronal excitability throughout the entire CNS. The stretch-activated channel TREK1 (K(2P)2.1) is expressed widely in brain and has been linked to depression, neuroprotection, pain perception, and epilepsy. Little, however, is known about the regulation of TREK1 expression on the transcriptional and translational level or about its trafficking to the plasma...
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