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Article

Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans.

Human brain mapping - 1 Feb 2010

Dillon Daniel G, Bogdan Ryan, Fagerness Jesen, Holmes Avram J, Perlis Roy H, Pizzagalli Diego A

Abstract excerpt

The TREK1 gene has been linked to a depression-resistant phenotype in rodents and antidepressant response in humans, but the neural mechanisms underlying these links are unclear. Because TREK1 is expressed in reward-related basal ganglia regions, it has been hypothesized that TREK1 genetic variation may be associated with anhedonic symptoms of depression. To investigate whether TREK1 genetic variation influences...

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Identifiers

PMID: 19621370
DOI: 10.1002/hbm.20858
PMCID: PMC2885957

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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