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Article

Estradiol and progesterone modify the effects of the serotonin reuptake transporter polymorphism on serotonergic responsivity to citalopram.

Experimental and clinical psychopharmacology - 1 Dec 2011

Michopoulos Vasiliki, Berga Sarah L, Wilson Mark E

Abstract excerpt

Individual vulnerability to psychopathologies is linked to a number of genetic polymorphisms including the serotonin transporter (5HTT) promoter polymorphic region (5HTTLPR). A single copy of the short variant (s-variant) allele of 5HTTLPR confers increased susceptibility to anxiety disorders and depression and decreased efficacy of serotonin-releasing agents in pharmacotherapy compared to the homozygous long...

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Identifiers

PMID: 21843009
DOI: 10.1037/a0025008
PMCID: PMC3253022

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