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Article

Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase.

Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2005

Prasad Harish C, Zhu Chong-Bin, McCauley Jacob L, Samuvel Devadoss J, Ramamoorthy Sammanda, Shelton Richard C, Hewlett William A, Sutcliffe James S, Blakely Randy D

Abstract excerpt

Human serotonin [5-hydroxytryptamine (5-HT)] transporters (hSERT, 5HTT, and SLC6A4) inactivate 5-HT after release and are prominent targets for therapeutic intervention in mood, anxiety, and obsessive-compulsive disorders. Multiple hSERT coding variants have been identified, although to date no comprehensive functional analysis of these variants has been reported. We transfected hSERT or 10 hSERT coding variants...

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Identifiers

PMID: 16055563
DOI: 10.1073/pnas.0501432102
PMCID: PMC1183547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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