Article
Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D.
Kidney international - 1 Dec 2011
van Roeyen Claudia R C, Eitner Frank, Boor Peter, Moeller Marcus J, Raffetseder Ute, Hanssen Lydia, Bücher Eva, Villa Luigi, Banas Miriam C, Hudkins Kelly L, Alpers Charles E, Ostendorf Tammo, Floege Jürgen
Abstract excerpt
Platelet-derived growth factor-D (PDGF-D), normally expressed in podocytes, mediates mesangial cell proliferation in vivo. To study this further, we created transgenic mice with podocyte-specific overexpression of PDGF-D. Hemizygous mice were grossly indistinguishable from wild-type littermates through 11 months of age; however, hemizygous mice older than 4 weeks commonly exhibited increased cell proliferation...
Topics
- Age Factors
- Animals
- Cell Proliferation
- Disease Models, Animal
- Female
- Gene Expression Regulation
- Glomerulonephritis
- HEK293 Cells
- Hemizygote
- Homozygote