Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

doi:10.1101/gad.8.16.1875

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Article

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

Genes & development - 15 Aug 1994

Levéen P, Pekny M, Gebre-Medhin S, Swolin B, Larsson E, Betsholtz C

Abstract excerpt

Platelet-derived growth factor (PDGF) affects the growth, migration, and function in vitro of mesenchymal cells, but little is known about its normal physiological functions in vivo. We show here that mice deficient for PDGF B die perinatally and display several anatomical and histological abnorm...

Topics

Anemia
Animals
Arteries
Base Sequence
DNA Probes
Erythroblastosis, Fetal
Female
Fetal Death
Heart Defects, Congenital
Hematologic Diseases
Humans
Infant, Newborn
Kidney
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Knockout

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