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Article

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

Genes & development - 15 Aug 1994

Levéen P, Pekny M, Gebre-Medhin S, Swolin B, Larsson E, Betsholtz C

Abstract excerpt

Platelet-derived growth factor (PDGF) affects the growth, migration, and function in vitro of mesenchymal cells, but little is known about its normal physiological functions in vivo. We show here that mice deficient for PDGF B die perinatally and display several anatomical and histological abnormalities. Kidney glomerular tufts do not form, apparently because of absence of mesangial cells. Instead, a single or a...

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Identifiers

PMID: 7958863
DOI: 10.1101/gad.8.16.1875

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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