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Article

Upregulated PD-1 signaling antagonizes glomerular health in aged kidneys and disease

14 Aug 2022

Abstract excerpt

With an aging population, kidney health becomes an important medical and socioeconomic factor. Kidney aging mechanisms are not well understood. We previously showed that podocytes isolated from aged mice exhibit increased expression of programmed cell death protein 1 (PD-1) surface receptor and its 2 ligands (PD-L1 and PD-L2). PDCD1 transcript increased with age in microdissected human glomeruli, which correlated...

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PMID: 35968783
DOI: 10.1172/jci156250

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