Article
Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis–associated glomerular injury
18 Mar 2014
Abstract excerpt
Injury to the specialized epithelial cells of the glomerulus (podocytes) underlies the pathogenesis of all forms of proteinuric kidney disease; however, the specific genetic changes that mediate podocyte dysfunction after injury are not fully understood. Here, we performed a large-scale insertional mutagenic screen of injury-resistant podocytes isolated from mice and found that increased expression of the gene...
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