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Article

Overexpression of VEGF-A in podocytes of adult mice causes glomerular disease.

Kidney international - 1 Jun 2010

Veron Delma, Reidy Kimberly J, Bertuccio Claudia, Teichman Jason, Villegas Guillermo, Jimenez Juan, Shen Wa, Kopp Jeffrey B, Thomas David B, Tufro Alda

Abstract excerpt

We sought to examine the pathogenic role of excessive VEGF-A expression in podocytes, since it has been reported that diabetic nephropathy and other glomerular diseases are associated with increased VEGF-A expression. The induction of podocyte-specific VEGF164 overexpression in adult transgenic mice led to proteinuria, glomerulomegaly, glomerular basement membrane thickening, mesangial expansion, loss of slit...

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Identifiers

PMID: 20375978
DOI: 10.1038/ki.2010.64

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