Quantitation of early clonal expansion of two mutant 61st codon c-Ha-ras alleles in DMBA/TPA treated mouse skin by nested PCR/RFLP.

doi:10.1093/carcin/17.12.2551

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Article

Quantitation of early clonal expansion of two mutant 61st codon c-Ha-ras alleles in DMBA/TPA treated mouse skin by nested PCR/RFLP.

Carcinogenesis - 1 Dec 1996

Finch J S, Albino H E, Bowden G T

Abstract excerpt

It has been hypothesized that tumor promotion in mouse skin involves clonal expansion of initiated cells with activated c-Harvey (Ha)-ras oncogene to give rise to benign tumors. We have used the two stage mouse skin carcinogenesis model using 7,12-dimethylbenz[a]anthracene (DMBA) as the initiator...

Topics

9,10-Dimethyl-1,2-benzanthracene
Alleles
Animals
Codon
Female
Genes, ras
Mice
Mutation
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Skin Neoplasms
Tetradecanoylphorbol Acetate

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