Article
Resistance of Ha-ras oncogene-induced progressor tumor variants to tumor necrosis factor and interferon-gamma.
Lymphokine and cytokine research - 1 Apr 1992
Fernandez A, Chen P W, Aggarwal B B, Ananthaswamy H N
Abstract excerpt
To elucidate the mechanisms by which tumor cells escape the immune defenses of the normal host, we have isolated progressor tumor variants from a regressor tumor cell line by transfection with an activated Ha-ras oncogene. We previously found that the progressor phenotype of Ha-ras-induced variants was not due to loss of tumor-specific or major histocompatibility complex antigens. In this study, we investigated...
Topics
- Animals
- Drug Resistance
- Female
- Genes, ras
- Genetic Variation
- Interferon-gamma
- Mice
- Mice, Inbred Strains
- Mice, Nude
- Transfection
- Tumor Cells, Cultured