Nontumorigenic squamous cell carcinoma line converted to tumorigenicity with methyl methanesulfonate without activation of HRAS or MYC.

doi:10.1073/pnas.87.4.1268

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Article

Nontumorigenic squamous cell carcinoma line converted to tumorigenicity with methyl methanesulfonate without activation of HRAS or MYC.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990

Milo G E, Shuler C, Kurian P, French B T, Mannix D G, Noyes I, Hollering J, Sital N, Schuller D, Trewyn R W

Abstract excerpt

Plasticity of human tumor populations could account for the reason why many tumorigenic human cell lines lose this feature when grown in culture. Methyl methanesulfonate (MMS) was used to convert premalignant squamous cell carcinoma (SCC) cell line SCC-83-01-82 to a malignant phenotype. The MMS-treated SCC-83-01-82 cells (MMS-SCC-83-01-82) produced progressively growing tumors in 5 of 11 splenectomized BALB/c...

Topics

Animals
Blotting, Southern
Carcinoma, Squamous Cell
Cell Line
Cell Transformation, Neoplastic
DNA, Neoplasm
Gene Amplification
Gene Expression Regulation, Neoplastic
Genes, ras
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Methyl Methanesulfonate

Mice

Mice, Nude

Neoplasm Transplantation

Nucleic Acid Hybridization

Protein-Tyrosine Kinases

Proto-Oncogene Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 2406716
DOI: 10.1073/pnas.87.4.1268
PMCID: PMC53455

Genes

HRAS
MYC
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2406716-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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