Article
The A beta 6w302 gene and molecular mechanisms of resistance to the spread of radiation-induced lymphoma in a mouse mutant, survivor-27.
Radiatsionnaia biologiia, radioecologiia - 1 Jan 2000
Liu Y, Savinov A Y, McMinimy D L, Kremlev S G, Chapoval A I, Egorov I K
Abstract excerpt
Metastatic tumors escape from immune response and spread in the body; survivors are very rare. Novel single exon genes A beta 4-7 and a pseudogene A beta 8 psi have been cloned from survivors. Their protein coding sequences are similar to MHC class II beta H2-Ab cDNA while their promoter is different from MHC promoters. The A beta 4 protein was demonstrated on macrophages (antigen presenting cells). The A beta...
Topics
- Animals
- H-2 Antigens
- Immunity, Innate
- Lymphoma
- Mice
- Mice, Mutant Strains
- Mutation
- Neoplasm Metastasis
- Neoplasms, Radiation-Induced