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Targeting of Rad51-dependent homologous recombination: implications for the radiation sensitivity of human lung cancer cell lines

1 Mar 2005

Abstract excerpt

The aim of the present work was to study the role of Rad51-dependent homologous recombination in the radiation response of non-small-cell lung cancer (NSCLC) cell lines. A dose- and time-dependent increase in the formation of Rad51 and gamma-H2AX foci with a maximum at about 4 and 1 h after irradiation, followed by a decrease, has been found. The relative fraction of cells with persisting Rad51 foci was 20-30% in...

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PMID: 15785736
DOI: 10.1038/sj.bjc.6602457

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