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ALTHEA Gold Libraries™: antibody libraries for therapeutic antibody discovery

21 Jan 2019

Abstract excerpt

We describe here the design, construction and validation of ALTHEA Gold Libraries™. These single-chain variable fragment (scFv), semisynthetic libraries are built on synthetic human well-known IGHV and IGKV germline genes combined with natural human complementarity-determining region (CDR)-H3/JH (H3J) fragments. One IGHV gene provided a universal VH scaffold and was paired with two IGKV scaffolds to furnish...

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PMID: 30663541
DOI: 10.1080/19420862.2019.1571879

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