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A Novel Heavy Domain Antibody Library with Functionally Optimized Complementarity Determining Regions

8 Oct 2013

Abstract excerpt

Today a number of synthetic antibody libraries of different formats have been created and used for the selection of a large number of recombinant antibodies. One of the determining factors for successful isolation of recombinant antibodies from libraries lies in the quality of the libraries i.e. the number of correctly folded, functional antibodies contained in the library. Here, we describe the construction of a...

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PMID: 24116173
DOI: 10.1371/journal.pone.0076834

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