Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages.

doi:10.1128/jb.172.5.2485-2490.1990

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Article

Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages.

Journal of bacteriology - 1 May 1990

Miller S I, Mekalanos J J

Abstract excerpt

The phoP genetic locus is a two-component regulatory system (phoP-phoQ) that controls the expression of genes essential for Salmonella typhimurium virulence and survival within macrophages. Strains with a phoP constitutive mutation (phenotype PhoPC) showed up to 10-fold greater expression of phoP-activated genes (pag loci) than did strains with a wild-type phoP locus (phenotype PhoP+). While the phoP constitutive...

Topics

Animals
Bacterial Proteins
Cell Survival
Cells, Cultured
Electrophoresis, Gel, Two-Dimensional
Electrophoresis, Polyacrylamide Gel
Gene Expression
Genes, Regulator
Genotype
Macrophages
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Molecular Weight

Phenotype

Salmonella Infections

Salmonella typhimurium

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 2185222
DOI: 10.1128/jb.172.5.2485-2490.1990
PMCID: PMC208887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2185222-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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