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Article

Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages.

Journal of bacteriology - 1 May 1990

Miller S I, Mekalanos J J

Abstract excerpt

The phoP genetic locus is a two-component regulatory system (phoP-phoQ) that controls the expression of genes essential for Salmonella typhimurium virulence and survival within macrophages. Strains with a phoP constitutive mutation (phenotype PhoPC) showed up to 10-fold greater expression of phoP-activated genes (pag loci) than did strains with a wild-type phoP locus (phenotype PhoP+). While the phoP constitutive...

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Identifiers

PMID: 2185222
DOI: 10.1128/jb.172.5.2485-2490.1990
PMCID: PMC208887

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Source receipt: pubmed, retrieved 7 Sept 2026.

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