Article
Comparative proteomic analysis of the PhoP regulon in Salmonella enterica serovar Typhi versus Typhimurium.
PloS one - 10 Sept 2009
Charles Richelle C, Harris Jason B, Chase Michael R, Lebrun Lauren M, Sheikh Alaullah, LaRocque Regina C, Logvinenko Tanya, Rollins Sean M, Tarique Abdullah, Hohmann Elizabeth L, Rosenberg Ian, Krastins Bryan, Sarracino David A, Qadri Firdausi, Calderwood Stephen B, Ryan Edward T
Abstract excerpt
BACKGROUND: S. Typhi, a human-restricted Salmonella enterica serovar, causes a systemic intracellular infection in humans (typhoid fever). In comparison, S. Typhimurium causes gastroenteritis in humans, but causes a systemic typhoidal illness in mice. The PhoP regulon is a well studied two component (PhoP/Q) coordinately regulated network of genes whose expression is required for intracellular survival of S....
Topics
- Animals
- Bacterial Proteins
- Bacterial Vaccines
- Gene Expression Regulation, Bacterial
- Humans
- Mice
- Models, Biological
- Mutation
- Peptides
- Proteomics