Article
The phoP locus influences processing and presentation of Salmonella typhimurium antigens by activated macrophages.
Molecular microbiology - 1 May 1995
Wick M J, Harding C V, Twesten N J, Normark S J, Pfeifer J D
Abstract excerpt
The destruction and processing of bacteria by activated macrophages facilitates the presentation of antigens to T cells and thereby promotes the induction of specific immunity. The PhoP-PhoQ regulatory system that controls the synthesis of many Salmonella proteins required for virulence and survi...
Topics
- Animals
- Antigen Presentation
- Antigens, Bacterial
- Bacterial Proteins
- Base Sequence
- Epitopes
- Gene Expression Regulation, Bacterial
- Lysosomes
- Macrophage Activation
- Macrophages
- Mice
- Mice, Inbred BALB C
- Mice, Inbred CBA
- Molecular Sequence Data
- Muramidase
- Mutation
- Ovalbumin
- Recombinant Fusion Proteins