Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium.

doi:10.1128/iai.58.11.3706-3710.1990

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Article

Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium.

Infection and immunity - 1 Nov 1990

Miller S I, Pulkkinen W S, Selsted M E, Mekalanos J J

Abstract excerpt

The defensin sensitivities of Salmonella typhimurium strains with mutations in the phoP/phoQ two-component virulence regulon were tested by using purified defensins NP-1 and NP-2. Strains with mutations in either gene of the regulatory pair (phoP [transcriptional activator] or phoQ [membrane sensor kinase]) had increased sensitivities to defensin. The predicted periplasmic domain of the PhoQ protein contained a...

Topics

Animals
Bacterial Proteins
Blood Bactericidal Activity
Blood Proteins
Defensins
Drug Resistance, Microbial
Gene Expression Regulation
Humans
Mutation
Neutrophils
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphotransferases

Rabbits

Salmonella typhimurium

Sensitivity and Specificity

Trans-Activators

Virulence

alpha-Defensins

Source

Open in PubMed Open full text

Identifiers

PMID: 2172166
DOI: 10.1128/iai.58.11.3706-3710.1990
PMCID: PMC313717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2172166-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium.PMID 2172166Read ↗

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