Article
Immunogenicity against human papillomavirus type 16 virus-like particles is strongly enhanced by the PhoPc phenotype in Salmonella enterica serovar Typhimurium.
Infection and immunity - 1 Feb 2004
Baud David, Benyacoub Jalil, Revaz Véronique, Kok Menno, Ponci Françoise, Bobst Martine, Curtiss Roy, De Grandi Pierre, Nardelli-Haefliger Denise
Abstract excerpt
Recombinant Salmonella strains have been widely used to deliver heterologous antigens and induce immune responses in vaccinated animals and humans. It remains to be established, however, how these bacteria mount an immune response; this has prevented the rational design of vaccines. Here we report for the first time that a particular genetic program, PhoPc, is necessary for recombinant Salmonella strains to...
Topics
- Animals
- Antibodies, Viral
- Bacterial Proteins
- Female
- Mice
- Mice, Inbred BALB C
- Papillomaviridae
- Phenotype
- Promoter Regions, Genetic
- Salmonella typhimurium