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Article

Constitutive mutations of the Salmonella enterica serovar Typhimurium transcriptional virulence regulator phoP.

Infection and immunity - 1 Jun 2000

Gunn J S, Ernst R K, McCoy A J, Miller S I

Abstract excerpt

The PhoP-PhoQ two-component system is necessary for the virulence of Salmonella spp. and is responsible for regulating several modifications of the lipopolysaccharide (LPS). Mutagenesis of the transcriptional regulator phoP resulted in the identification of a mutant able to activate transcription of regulated genes approximately 100-fold in the absence of PhoQ. Sequence analysis showed two single-base alterations...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10816543
DOI: 10.1128/IAI.68.6.3758-3762.2000
PMCID: PMC97674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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