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Article

Pigment epithelium-derived factor (PEDF) promotes tumor cell death by inducing macrophage membrane tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

The Journal of biological chemistry - 14 Oct 2011

Ho Tsung-Chuan, Chen Show-Li, Shih Shou-Chuan, Chang Shing-Jyh, Yang Su-Lin, Hsieh Jui-Wen, Cheng Huey-Chuan, Chen Lee-Jen, Tsao Yeou-Ping

Abstract excerpt

Pigment epithelium-derived factor (PEDF) is an intrinsic anti-angiogenic factor and a potential anti-tumor agent. The tumoricidal mechanism of PEDF, however, has not been fully elucidated. Here we report that PEDF induces the apoptosis of TC-1 and SK-Hep-1 tumor cells when they are cocultured with bone marrow-derived macrophages (BMDMs). This macrophage-mediated tumor killing is prevented by blockage of...

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PMID: 21846721
DOI: 10.1074/jbc.M111.266064
PMCID: PMC3195575

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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