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Article

The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2.

Molecular cell - 16 Feb 2017

Hartwig Torsten, Montinaro Antonella, von Karstedt Silvia, Sevko Alexandra, Surinova Silvia, Chakravarthy Ankur, Taraborrelli Lucia, Draber Peter, Lafont Elodie, Arce Vargas Frederick, El-Bahrawy Mona A, Quezada Sergio A, Walczak Henning

Abstract excerpt

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known for specifically killing cancer cells, whereas in resistant cancers, TRAIL/TRAIL-R can promote metastasis via Rac1 and PI3K. It remains unknown, however, whether and to what extent TRAIL/TRAIL-R signaling in cancer cells can affect the immune microenvironment. Here we show that TRAIL-triggered cytokine secretion from TRAIL-resistant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28212753
DOI: 10.1016/j.molcel.2017.01.021
PMCID: PMC5316415

Genes

CCL2
CCR2
FADD
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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