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Article

Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2002

Cretney Erika, Takeda Kazuyoshi, Yagita Hideo, Glaccum Moira, Peschon Jacques J, Smyth Mark J

Abstract excerpt

We have previously implicated TNF-related apoptosis-inducing ligand (TRAIL) in innate immune surveillance against tumor development. In this study, we describe the use of TRAIL gene-targeted mice to demonstrate the key role of TRAIL in suppressing tumor initiation and metastasis. Liver and spleen mononuclear cells from TRAIL gene-targeted mice were devoid of TRAIL expression and TRAIL-mediated cytotoxicity. TRAIL...

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Source

Identifiers

PMID: 11801676
DOI: 10.4049/jimmunol.168.3.1356

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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