Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pigment epithelium-derived factor: a multimodal tumor inhibitor

1 Jul 2006

Abstract excerpt

Pigment epithelium-derived factor (PEDF), a noninhibitory member of the serine protease inhibitor (serpin) family, is a well-known potent endogenous inhibitor of angiogenesis. It has been known for years to be aberrantly expressed in ocular disorders, but in recent years, down-regulation has been shown to be prevalent in a range of cancers as well. This review describes the trimodal anticancer activities of this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis and VEGF in Cancer
Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16891449
DOI: 10.1158/1535-7163.mct-06-0107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pigment epithelium-derived factor: a multimodal tumor inhibitorPMID 16891449Read ↗

PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseasesSemantic proximity Read ↗

Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potentialSemantic proximity Read ↗

Potential of Protein-based Anti-metastatic Therapy with Serpins and Inter α-Trypsin InhibitorsSemantic proximity Read ↗

Overexpression of Pigment Epithelium-Derived Factor Decreases Angiogenesis and Inhibits the Growth of Human Malignant Melanoma Cells in VivoSemantic proximity Read ↗

Changes in the gene expression profile of A375 human melanoma cells induced by overexpression of multifunctional pigment epithelium-derived factor.Semantic proximity Read ↗

Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye DiseaseSemantic proximity Read ↗

Targeting vascular endothelial growth factor using retinal gene therapySemantic proximity Read ↗

‘Loss of pigment epithelium-derived factor enables migration, invasion and metastatic spread of human melanoma’Semantic proximity Read ↗

CRISPR Technology for Ocular AngiogenesisSemantic proximity Read ↗

VEGF-B: a thing of beautySemantic proximity Read ↗

Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF.Semantic proximity Read ↗

VEGFR1–mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.