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Article

Genetic variation in 5-hydroxytryptamine transporter expression causes adaptive changes in 5-HT₄ receptor levels.

The international journal of neuropsychopharmacology - 1 Sept 2012

Jennings Katie Ann, Licht Cecilie Löe, Bruce Aynsley, Lesch Klaus-Peter, Knudsen Gitte Moos, Sharp Trevor

Abstract excerpt

Genetic variation in 5-HT transporter (5-HTT) expression is a key risk factor for psychiatric disorder and has been linked to changes in the expression of certain 5-HT receptor subtypes. This study investigated the effect of variation in 5-HTT expression on 5-HT₄ receptor levels in both 5-HTT knockout (KO) and overexpressing (OE) mice using autoradiography with the selective 5-HT₄ receptor radioligand,...

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PMID: 21846421
DOI: 10.1017/S1461145711001258

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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