Article
Adaptive changes of serotonin 5-HT2A receptors in mice lacking the serotonin transporter.
Neuroscience letters - 5 Mar 1999
Rioux A, Fabre V, Lesch K P, Moessner R, Murphy D L, Lanfumey L, Hamon M, Martres M P
Abstract excerpt
The serotonin transporter (5-HTT) plays a key-role in the control of serotoninergic neurotransmission and is the target of some antidepressants. Possible adaptive changes in brain 5-HT2A receptors were investigated in knock-out mice that do not express the 5-HTT. Autoradiographic labeling of these receptors by the selective antagonist [3H]MDL 100,907 and saturation experiments with cortical membranes revealed:...
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