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Article

Evidence that genetic variation in 5-HT transporter expression is linked to changes in 5-HT2A receptor function.

Neuropharmacology - 1 Apr 2008

Jennings K A, Sheward W J, Harmar A J, Sharp T

Abstract excerpt

Variability in expression of the 5-HT transporter (5-HTT) gene in the human population has been associated with a range of behavioural phenotypes. The underlying mechanisms are unclear but may involve changes in 5-HT receptor levels and/or signalling. The present study used a novel 5-HTT overexpressing transgenic mouse to test the hypothesis that variability in 5-HTT expression may alter 5-HT(2A) receptor...

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Source

Identifiers

PMID: 18241894
DOI: 10.1016/j.neuropharm.2007.12.001

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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