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Article

A genome-wide association study identifies two new risk loci for Graves' disease.

Nature genetics - 14 Aug 2011

Chu Xun, Pan Chun-Ming, Zhao Shuang-Xia, Liang Jun, Gao Guan-Qi, Zhang Xiao-Mei, Yuan Guo-Yue, Li Chang-Gui, Xue Li-Qiong, Shen Min, Liu Wei, Xie Fang, Yang Shao-Ying, Wang Hai-Feng, Shi Jing-Yi, Sun Wei-Wei, Du Wen-Hua, Zuo Chun-Lin, Shi Jin-Xiu, Liu Bing-Li, Guo Cui-Cui, Zhan Ming, Gu Zhao-Hui, Zhang Xiao-Na, Sun Fei, Wang Zhi-Quan, Song Zhi-Yi, Zou Cai-Yan, Sun Wei-Hua, Guo Ting, Cao Huang-Ming, Ma Jun-Hua, Han Bing, Li Ping, Jiang He, Huang Qiu-Hua, Liang Liming, Liu Li-Bin, Chen Gang, Su Qing, Peng Yong-De, Zhao Jia-Jun, Ning Guang, Chen Zhu, Chen Jia-Lun, Chen Sai-Juan, Huang Wei, Song Huai-Dong

Abstract excerpt

Graves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic architecture of Graves' disease, we conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases) and 1,516 controls. We further evaluated a group of associated SNPs in a second set of 3,994 cases and 3,510...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21841780
DOI: 10.1038/ng.898

Genes

RNASET2
TSHR
CCR6
CHRNA9
CTLA4
FCRL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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