Genome-wide association study and polygenic risk prediction of hypothyroidism

Abstract excerpt

<title>Abstract</title> <p>We performed a genome-wide meta-analysis of hypothyroidism (114,813 cases and 1,043,713 controls), free thyroxine (186,409 individuals) and thyroid stimulating hormone (459,999 individuals). We have identified 326 loci associated with hypothyroidism, including 156 that have not been previously reported, with 25 loci linked through thyroid hormones. We found that many of the hypothyroidi...

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• Autoimmune Diseases
• California
• Forkhead Transcription Factors
• Histocompatibility Antigens Class I
• Hypothyroidism
• Protein Tyrosine Phosphatase, Non-Receptor Type 22
• Proto-Oncogene Proteins c-vav
• Surveys and Questionnaires

Identifiers and source

Literature Corpus work

3a856f0a-3ca3-5544-9b87-9555cc9a244b

DOI

10.21203/rs.3.rs-3978229/v1