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Article

Activation of Raf-1 in human pancreatic adenocarcinoma.

The Journal of surgical research - 1 Apr 1997

Berger D H, Jardines L A, Chang H, Ruggeri B

Abstract excerpt

Point mutations in the Ras oncogene cause Ras to remain in its active GTP-bound state sending signals downstream continuously. Since 75 to 90% of all human pancreatic ductal adenocarcinomas harbor activating mutations at codon 12 of the K-ras oncogene it was our belief that Raf-1-MEK-MAPK will be activated in the majority of human pancreatic cancers. The aim of this study was to confirm activation of Raf-1 in...

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Source

Identifiers

PMID: 9202670
DOI: 10.1006/jsre.1997.5022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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