Article
Activation of Raf-1 in human pancreatic adenocarcinoma.
The Journal of surgical research - 1 Apr 1997
Berger D H, Jardines L A, Chang H, Ruggeri B
Abstract excerpt
Point mutations in the Ras oncogene cause Ras to remain in its active GTP-bound state sending signals downstream continuously. Since 75 to 90% of all human pancreatic ductal adenocarcinomas harbor activating mutations at codon 12 of the K-ras oncogene it was our belief that Raf-1-MEK-MAPK will be...
Topics
- Adenocarcinoma
- Calcium-Calmodulin-Dependent Protein Kinases
- Enzyme Activation
- Gene Expression Regulation
- Genes, ras
- Humans
- Mutation
- Pancreatic Neoplasms
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-raf
- Tumor Cells, Cultured