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Article

A new kinetic framework for synaptic vesicle trafficking tested in synapsin knock-outs.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Aug 2011

Gabriel Thomas, García-Pérez Elizabeth, Mahfooz Kashif, Goñi Joaquín, Martínez-Turrillas Rebeca, Pérez-Otaño Isabel, Lo Donald C, Wesseling John F

Abstract excerpt

At least two rate-limiting mechanisms in vesicle trafficking operate at mouse Schaffer collateral synapses, but their molecular/physical identities are unknown. The first mechanism determines the baseline rate at which reserve vesicles are supplied to a readily releasable pool. The second causes the supply rate to depress threefold when synaptic transmission is driven hard for extended periods. Previous models...

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Identifiers

PMID: 21832187
DOI: 10.1523/JNEUROSCI.1447-11.2011
PMCID: PMC6623131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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