Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tyrosine phosphorylation of synapsin I by Src regulates synaptic-vesicle trafficking.

Journal of cell science - 1 Jul 2010

Messa Mirko, Congia Sonia, Defranchi Enrico, Valtorta Flavia, Fassio Anna, Onofri Franco, Benfenati Fabio

Abstract excerpt

Synapsins are synaptic vesicle (SV)-associated phosphoproteins involved in the regulation of neurotransmitter release. Synapsins reversibly tether SVs to the cytoskeleton and their phosphorylation by serine/threonine kinases increases SV availability for exocytosis by impairing their association with SVs and/or actin. We recently showed that synapsin I, through SH3- or SH2-mediated interactions, activates Src and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Membrane Potentials
Share to Protein Multimerization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Rats, Sprague-Dawley

Share to src-Family Kinases

Share to Synapsins

Share to Synaptic Vesicles

Share to Tyrosine

Source

Identifiers

PMID: 20530578
DOI: 10.1242/jcs.068445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tyrosine phosphorylation of synapsin I by Src regulates synaptic-vesicle trafficking.PMID 20530578Read ↗

Essential functions of synapsins I and II in synaptic vesicle regulation.Semantic proximity Read ↗

Phosphorylation of synapsin domain A is required for post-tetanic potentiation.Semantic proximity Read ↗

SUMOylation of synapsin Ia maintains synaptic vesicle availability and is reduced in an autism mutation.Semantic proximity Read ↗

Rasopathy-Associated Mutation Ptpn11D61Y has Age-Dependent Effect on Synaptic Vesicle Recycling.Semantic proximity Read ↗

Different presynaptic roles of synapsins at excitatory and inhibitory synapses.Semantic proximity Read ↗

Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity.Semantic proximity Read ↗

Regulation of neurotransmitter release by synapsin III.Semantic proximity Read ↗

Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly.Semantic proximity Read ↗

PTPN11/Corkscrew Activates Local Presynaptic Mapk Signaling to Regulate Synapsin, Synaptic Vesicle Pools, and Neurotransmission Strength, with a Dual Requirement in Neurons and Glia.Semantic proximity Read ↗

A new kinetic framework for synaptic vesicle trafficking tested in synapsin knock-outs.Semantic proximity Read ↗

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.Semantic proximity Read ↗

Cooperative regulation of neurotransmitter release by Rab3a and synapsin II.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.