Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses.

Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2012

Lou Xuelin, Fan Fan, Messa Mirko, Raimondi Andrea, Wu Yumei, Looger Loren L, Ferguson Shawn M, De Camilli Pietro

Abstract excerpt

Endocytic recycling of synaptic vesicles after exocytosis is critical for nervous system function. At synapses of cultured neurons that lack the two "neuronal" dynamins, dynamin 1 and 3, smaller excitatory postsynaptic currents are observed due to an impairment of the fission reaction of endocyto...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2
Share to Cerebral Cortex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dynamins

Share to Mice, Knockout

Share to Neurons

Share to Synaptic Transmission

Share to Synaptic Vesicles

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 22308498
DOI: 10.1073/pnas.1121626109
PMCID: PMC3286982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22308498-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses.PMID 22308498Read ↗

Complexin Mutants Reveal Partial Segregation between Recycling Pathways That Drive Evoked and Spontaneous Neurotransmission.Semantic proximity Read ↗

PRRT2 Is a Key Component of the Ca2+-Dependent Neurotransmitter Release MachinerySemantic proximity Read ↗

Rasopathy-Associated Mutation Ptpn11D61Y has Age-Dependent Effect on Synaptic Vesicle Recycling.Semantic proximity Read ↗

FMRP sustains presynaptic function via control of activity-dependent bulk endocytosisSemantic proximity Read ↗

Vti1a identifies a vesicle pool that preferentially recycles at rest and maintains spontaneous neurotransmission.Semantic proximity Read ↗

In vivo synaptic recovery following optogenetic hyperstimulation.Semantic proximity Read ↗

Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions.Semantic proximity Read ↗

VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.Semantic proximity Read ↗

How does synaptotagmin trigger neurotransmitter release?Semantic proximity Read ↗

Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release.Semantic proximity Read ↗

Synaptic vesicle protein 2 enhances release probability at quiescent synapses.Semantic proximity Read ↗

Synaptic vesicles: test for a role in presynaptic calcium regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.