Article
Opposing functions of two sub-domains of the SNARE-complex in neurotransmission.
The EMBO journal - 4 Aug 2010
Weber Jens P, Reim Kerstin, Sørensen Jakob B
Abstract excerpt
The SNARE-complex consisting of synaptobrevin-2/VAMP-2, SNAP-25 and syntaxin-1 is essential for evoked neurotransmission and also involved in spontaneous release. Here, we used cultured autaptic hippocampal neurons from Snap-25 null mice rescued with mutants challenging the C-terminal, N-terminal and middle domains of the SNARE-bundle to dissect out the involvement of these domains in neurotransmission. We report...
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