Article
A small pool of vesicles maintains synaptic activity in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2011
Denker Annette, Bethani Ioanna, Kröhnert Katharina, Körber Christoph, Horstmann Heinz, Wilhelm Benjamin G, Barysch Sina V, Kuner Thomas, Neher Erwin, Rizzoli Silvio O
Abstract excerpt
Chemical synapses contain substantial numbers of neurotransmitter-filled synaptic vesicles, ranging from approximately 100 to many thousands. The vesicles fuse with the plasma membrane to release neurotransmitter and are subsequently reformed and recycled. Stimulation of synapses in vitro generally causes the majority of the synaptic vesicles to release neurotransmitter, leading to the assumption that synapses...
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